1 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Information to be included in Statements filed pursuant to Rules 13d-1 (b), (c) and (d) and Amendments thereto filed pursuant to Rule 13d-2(b) Under the Securities Exchange Act of 1934 (Amendment No. __)* Harvard Bioscience, Inc. (Name of Issuer) Common Stock, Par Value $0.01 Per Share (Title of Class of Securities) 416906105 (CUSIP Number) December 31, 2000 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: / / Rule 13d-1(b) / / Rule 13d-1(c) / X / Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). **The total number of shares reported herein is 1,963,825 shares, which constitutes approximately 7.9% of the 24,782,422 shares of Common Stock deemed outstanding pursuant to Rule 13d-3(d)(1)(i) under the Act. Unless otherwise stated, all ownership percentages set forth herein assume that there are 24,782,422 shares outstanding.

2 SCHEDULE 13G - -------------------------------------------------------------------------------- CUSIP No. 416906105 Page 2 of 6 Pages - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS FIRST NEW ENGLAND CAPITAL LIMITED PARTNERSHIP - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a)/___/ (b)/ X / - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION CONNECTICUT - -------------------------------------------------------------------------------- NUMBER 5 SOLE VOTING POWER 1,963,825 OF SHARES ----------------------------------------------------- BENEFICIALLY 6 SHARED VOTING POWER -0- OWNED BY ----------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER 1,963,825 REPORTING PERSON ----------------------------------------------------- WITH 8 SHARED DISPOSITIVE POWER -0- - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,963,825 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* /___/ - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.9% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - --------------------------------------------------------------------------------

3 SCHEDULE 13G - -------------------------------------------------------------------------------- CUSIP No. 416906105 Page 3 of 6 Pages - -------------------------------------------------------------------------------- Item 1(a). Name of Issuer: Harvard Bioscience, Inc. Item 1(b). Address of Issuer's Principal Executive Offices: 84 October Hill Road Holliston, Massachusetts 01746-1371 Item 2(a). Name of Person Filing: See Item 1 of Page 2 Item 2(b). Address of Principal Business Office or, if none, Residence: 100 Pearl Street Hartford, CT Item 2(c). Citizenship: See Item 4 of Page 2 Item 2(d). Title of Class of Securities: Common Stock Item 2(e). CUSIP Number: 416906105 Item 3. If this statement is filed pursuant to Rules 13d-1(b) or 13d-2(b) or (c), check whether the person filing is a: (a) [ ] Broker or dealer registered under Section 15 of the Act, (b) [ ] Bank as defined in Section 3(a)(6) of the Act, (c) [ ] Insurance Company as defined in Section 3(a)(19) of the Act, (d) [ ] Investment Company registered under Section 8 of the Investment Company Act, (e) [ ] Investment Adviser in accordance with Rule 13d-1(b)(1)(ii)(E), (f) [ ] Employee Benefit Plan or Endowment Fund in accordance with Rule 13d-1(b)(1)(ii)(F), (g) [ ] Parent Holding Company or control person in accordance with Rule 13d-1(b)(1)(ii)(G), (h) [ ] Savings Association as defined in Section 3(b) of the Federal Deposit Insurance Act, (i) [ ] Church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act, (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J). Not applicable to Reporting Person

4 SCHEDULE 13G - -------------------------------------------------------------------------------- CUSIP No. 416906105 Page 4 of 6 Pages - -------------------------------------------------------------------------------- Item 4. Ownership (a) Amount Beneficially Owned: See Item 9 of Page 2 (b) Percent of Class: See Item 11 of Page 2 (c) Number of shares as to which such person has: (i) Sole power to vote or to direct the vote - See Item 5 of Page 2 (ii) Shared power to vote or to direct the vote - See Item 6 of Page 2 (iii) Sole power to dispose or to direct the disposition of - See Item 7 of Page 2 (iv) Shared power to dispose or to direct the disposition of - See Item 8 of Page 2 Reporting Person First New England Capital Limited Partnership ("FNEC") The aggregate number of shares of the stock that FNEC owns beneficially, pursuant to Rule 13d-3 of the Act, is 1,963,825, which constitutes approximately 7.9% of the outstanding shares of the common stock. Controlling Persons FINEC, Corp. Because of its position as the managing general partner of FNEC, FINEC Corp. may, pursuant to Rule 13d-3 of the Act, be deemed to be the beneficial owner of 1,963,825 shares of the common stock, which constitutes approximately 7.9% of the outstanding shares of the stock. Richard C. Klaffky, Jr. Because of his position as an executive officer, director and shareholder of FINEC, Mr. Klaffky may, pursuant to Rule 13d-3 of the Act, be deemed to be the beneficial owner of 1,963,825 shares of the common stock, which constitutes approximately 7.9% of the 24,782,422 shares of the stock deemed outstanding pursuant to Rule 13d-3(d)(1)(i). Mr. Klaffky disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein. Item 5. Ownership of Five Percent or Less of a Class: Not Applicable to Reporting Person

5 SCHEDULE 13G - -------------------------------------------------------------------------------- CUSIP No. 416906105 Page 5 of 6 Pages - -------------------------------------------------------------------------------- Item 6. Ownership of More than Five Percent on Behalf of Another Person: Not Applicable to Reporting Person Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company: Not applicable to Reporting Person Item 8. Identification and Classification of Members of the Group: Not applicable to Reporting Person Item 9. Notice of Dissolution of a Group: Not applicable to Reporting Person Item 10. Certification: Not applicable to Reporting Person.

6 SCHEDULE 13G - -------------------------------------------------------------------------------- CUSIP No. 416906105 Page 6 of 6 Pages - -------------------------------------------------------------------------------- Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. First New England Capital, Limited Partnership By: FINEC Corp. General Partner /s/ Richard C. Klaffky, Jr. ------------------------------------- Richard C. Klaffky, Jr. President